What is this study about?
Understanding Atrial Fibrillation
Atrial fibrillation (AF) is a heart condition where the heartbeat is irregular and often too fast. This happens when the upper chambers of the heart (the atria) beat out of sync with the lower chambers (the ventricles). If AF is not treated, it can cause blood clots to form in the heart. These clots can raise the risk of stroke, heart failure, or other serious problems.
Because of these risks, it’s important to treat AF, especially if it happens often or doesn’t go away on its own. One common treatment is called catheter ablation. In this procedure, a doctor places a thin, flexible tube (catheter) into a blood vessel and guides it to the heart. Heat or cold energy is then used to make small scars in heart tissue. These scars block the faulty signals that cause the heart to beat irregularly.
What Happens During Ablation
The most common area targeted during ablation is near the veins that bring blood from the lungs to the heart, called the pulmonary veins. This is known as pulmonary vein isolation (PVI).
While ablation can help many patients, AF sometimes comes back, and people may need the procedure again. Usually, doctors repeat the same treatment in the pulmonary veins.
What This Study Is Testing
This study is testing whether adding treatment to another area of the heart, called the posterior wall, can lead to better results. Patients in the study will be placed into one of two groups:
By comparing these two groups, the study aims to determine whether treating both areas helps reduce AF and improve quality of life more effectively than treating the pulmonary veins alone.
Regardless of which group you’re placed in, you will continue having regular follow-up visits with your cardiologist over the course of four years, aligning with the traditional standard of care.
In addition to these regular visits, there are a few study-specific items you will be asked to complete:
- Complete a questionnaire about your symptoms and overall quality of life
- Wear a small ECG patch on your chest for about one week at different points during the follow-up period
- The ECG patch records your heart’s rhythm so doctors can monitor it over a longer period of time
Who can join this study?
You can talk to your doctor about joining the study if:
You are 18 years or older
You have received one prior PVI ablation procedure for persistent AF
You have recurrent or persistent AF despite prior ablation
You are eligible for repeat ablation procedure
You are willing to comply with all post-procedural follow-up requirements and to sign informed consent
There are other things to consider as well. Only you and your doctor can decide if this study is right for you.
Registry
During your repeat ablation procedure, your doctor will first do a test called cardiac mapping. This test checks whether your atrial fibrillation is coming back because the abnormal connection between the left atrium and the pulmonary vein has grown back.
If this connection is found, you will stay in the study and continue as planned. If the connection is not found, you won’t take part in the randomization part of the study. Instead, you will receive a different ablation procedure. Even if you are not randomized, you will still be followed the same way as other participants.
In addition to this, your information will be entered into a registry so researchers can track how well the standard treatment works for people who don’t have the left atrium–pulmonary vein reconnection.
Benefits and Risks
Potential Benefits
Potential Risks
Frequently asked questions
At 30 sites across the United States. Please see the map below for exact locations.
Contact Us
601 Elmwood Ave,
Rochester, NY
14642
repeataf.mail@urmc.rochester.edu
Your participation can help future generations
